Aim The aim of the present preliminary case-control study was to test the sensitivity and specificity of salivary pipecolic acid in predicting head and neck squamous cell carcinoma (HNSCC). Methods High-performance liquid chromatography was used for the analysis of non-stimulated saliva samples from 40 individuals: 20 in the case group (recently diagnosed with untreated HNSCC) and 20 in the control group (individuals without cancer). Both groups included patients taking daily oral hypoglycemic drugs (comorbidity). The case and control groups were matched at a proportion of 1:1 for sex and comorbidity. Results Mean salivary levels of pipecolic acid were 169.38 ng/mL in the case group and 114.66 ng/mL in the control group (p<0.001). Individuals who took oral hypoglycemic drugs had higher levels of pipecolic acid in both the case and control groups (p<0.001). The receiver operating characteristic curve analysis revealed 90% sensitivity and 65% specificity for head and neck cancer, with an area under the curve of 0.838 between the case and control groups. Conclusions Pipecolic acid had high sensitivity for the diagnosis of HNSCC but low specificity in the sample analyzed. Our findings suggest that salivary pipecolic acid levels are associated with glucose homeostasis. Studies with larger samples are required to evaluate the specificity of this metabolite.

Abstract Hyposalivation and sensation of dry mouth (xerostomia) are one of the most common adverse effects in the treatment of patients with head and neck cancer. Objective: This study evaluates the prevalence of late hyposalivation and associated factors in survivors of squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, or larynx treated with radiotherapy with or without concomitant chemotherapy. Methodology: A cross-sectional study was conducted with 88 patients who had concluded radiotherapy at least three months before the study, at a referral center for the treatment of head and neck cancer in the Southern region of Brazil. Hyposalivation was evaluated based on the stimulated salivary flow rate using the spitting method. Multivariate analysis using binary logistic regression was performed to determine the associations between hyposalivation and clinical and demographic variables. Results: Hyposalivation was found in 78.41% of the sample and the mean radiation dose was 63.01 Gy (±9.58). In the crude model of the multivariate analysis, hyposalivation was associated with higher doses of radiation (p=0.038), treatment with concomitant radiotherapy and chemotherapy (p=0.005), and time elapsed since the end of radiotherapy (p=0.025). In the adjusted model of the multivariate analysis, hyposalivation was only associated with dose and time elapsed. Patient who received higher doses of radiation had a 4.25-fold greater chance of presenting hyposalivation, whereas a longer time elapsed since the end of radiotherapy exerted a 75% protective effect against the occurrence of hyposalivation. Conclusion: Hyposalivation is a highly prevalence late-onset side effect of radiotherapy in patients treated for head and neck cancer, with a greater chance of occurrence among those who received higher doses of radiation and those who ended therapy less than 22 months before our study. Concomitant chemotherapy and radiotherapy does not seem to increase the chances of hyposalivation compared to radiotherapy alone.

Abstract The sense of coherence (SOC) is a measure of global orientation regarding the ability of individuals to cope with stressful situations. The aim of the present study was to evaluate the association between SOC and quality of life (QoL) and clinical and sociodemographic characteristics among survivors of oral, oropharynx, hypopharynx, or larynx cancer. A cross-sectional study was conducted with 90 cancer patients in follow up at the Santa Maria University Hospital in southern Brazil who had completed conformal 3D radiotherapy at least three months earlier. QoL was assessed using the University of Washington Quality of Life (UW-QOL) questionnaire and SOC was measured using the Brazilian version of the SOC-13 questionnaire. Data on socio-demographic characteristics and the disease were obtained from patients’ charts. Oral clinical conditions were also evaluated. Associations between exploratory variables and mean UW-QOL scores were evaluated through Poisson regression and the results were presented as rate ratios (RR) and 95% confidence intervals (CI). The mean overall UW-QOL score was 67.90 (± 18.71). Moderate and high SOC scores were associated with higher mean UW-QOL scores, that is, individuals with a stronger SOC demonstrated better QoL, (p < 0.05). Regarding the clinical variables, individuals with advanced stage cancer and those with hyposalivation and trismus had poorer QoL (p < 0.05). Patients with a greater SOC reported a better quality of life. Our findings show the importance of focusing on psychosocial factors, which can alleviate the impact caused by the disease and improve the QoL of these patients.

INTRODUÇÃO: A hipertensão arterial sistêmica é um dos mais importantes fatores de risco de doenças cardiovasculares e uma das doenças crônicas mais prevalentes no Brasil e na população mundial.OBJETIVO: Avaliar a prevalência de hipertensão e pré-hipertensão, fatores associados e adesão ao tratamento anti-hipertensivo em uma amostra de pacientes odontológicos de uma faculdade particular do Rio Grande do Sul, Brasil.MATERIAL E MÉTODO: Participaram deste estudo 250 pacientes de ambos os gêneros, com idade igual ou superior a 18 anos. Foram obtidos dados demográficos, história de hipertensão arterial e outras doenças sistêmicas, informações sobre o uso de medicação anti-hipertensiva e tabagismo, e realizadas medidas antropométricas. A adesão ao tratamento foi avaliada pelo teste de Morisky e Green. Três aferições de pressão arterial foram realizadas por um Cirurgião-Dentista e a medição média das últimas duas tomadas foi utilizada na presente análise.RESULTADO: A idade média dos pacientes foi de 46,6 (±13,8) anos. Trinta por cento apresentavam pré-hipertensão e 36%, hipertensão arterial sistêmica. Destes, 28,9% não conheciam sua condição de hipertensão. A hipertensão mostrou associação estatisticamente significante com aumento da idade (p<0,001) e diabetes (p=0,009). Dentre os pacientes em tratamento anti-hipertensivo, 58,1% não eram aderentes, enquanto 41,9% não estavam com a pressão arterial controlada.CONCLUSÃO: Na presente amostra, observou-se uma alta prevalência de pré-hipertensão e hipertensão não diagnosticadas, bem como alta taxa da doença não controlada. Estes resultados apontam para a importância da aferição da pressão arterial rotineiramente durante as visitas odontológicas.

INTRODUCTION: Hypertension is one of the most important risk factors for cardiovascular diseases and one of the most prevalent chronic diseases in Brazil and in the world population.OBJECTIVE: Assess the prevalence of hypertension and prehypertension, associated factors and adherence to antihypertensive therapy in a sample of dental patients of a private dentistry school in the state of Rio Grande do Sul, Brazil.MATERIAL AND METHOD: The participants of this study were 250 patients of both genders, aged over 18 years. Demographic data, history of hypertension and other systemic diseases, information about the use of antihypertensive drugs and smoking were obtained, and anthropometric measurements were performed. Adherence to treatment was evaluated by Morisky-Green test. Three blood pressure measurements were made by a dentist, and the average of the last two measurements was used in this analysis.RESULT: The mean age of patients was 46.6 (±13.8) years. Thirty percent had prehypertension and 36% had hypertension. Of these hypertensive patients, 28.9% were unaware of their hypertensive condition. Hypertension was statistically associated with increasing age (p<0.001) and diabetes (p=0.009). Among patients on antihypertensive treatment, 58.1% were non-adherent, whilst 41.9% had no controlled blood pressure.CONCLUSION: In the present study we observed a high prevalence of prehypertension and undiagnosed hypertension, as well as high rate of uncontrolled disease. These results point to the importance of blood pressure measurements during dental visits.